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CAS NO.50-23-7
Hydrocortisone is a white to off-white crystalline powder, practically insoluble in water,sparingly soluble in acetone and in alcohol, slightly in methylene chloride. Hydrocortisone is an adrenal cortical hormone cortin drug, and it has glucose metabolism, anti-inflammatory, anti-allergic pharmacotherapy, and anti-venoms effects. It is mainly used in the replacement therapy of adrenal cortical dysfunction.
Specification
Appearance(Ph.Eur.) A white or almost white,crystalline powder
Solubility(Ph.Eur.)(annual) Practically insoluble in water,sparingly soluble in acetone and in
alcohol,slightly in methylene chloride
Specific optical rotation(Ph.Eur.) 150°~156°
Loss on drying(Ph.Eur.) Not more than 1.0%
Residue on ignition(USP) Not more than 0.5%
Any individual impurity Not more than 0.5%
Sum of impurities Not more than 1.5%
Chromatographic purity(USP)
Any individual impurity Not more than 0.5%
Sum of impurities Not more than 2.0%
Assay 97.0%~103.0%
Residual solvent(In-house)
Methanol Not more than 500ppm
Ethanol Not more than 2000ppm
Methylene chloride Not more than 600ppm
Chloroform Not more than 60ppm
Particle 90% not more than 15microns
Application
Hydrocortisone is an adrenal cortical hormone cortin drug, and it has glucose metabolism, anti-inflammatory, anti-allergic pharmacotherapy, and anti-venoms effects. It is mainly used in the replacement therapy of adrenal cortical dysfunction.