Hefei TNJ chemical industry co.,ltd
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CAS NO.5560-59-8
Alverine citrate 5560-59-8
The professional manufacuture in China.
Description: Alverine Citrate is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine Citrate acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. It is used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine Citrate is formulated as the citrate salt (5982-87-6).
Application : Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine Citrate is also under investigation to increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells.
|
Item |
Results |
Specifications |
|
|
Appearance |
White or almost white |
Conforms |
|
|
Melting point |
≤104°C |
102.5-103.5% |
|
|
Solubility |
------ |
Conforms |
|
|
Identification |
IR |
Conforms |
|
|
Ph(0.5% W/V soluble in water) |
3.5-4.5 |
4.1 |
|
|
Related substances GC |
Impurity A |
<0.1% |
Not detected |
|
|
ImpurityB |
<0.1% |
Not detected |
|
|
ImpurityC |
<0.2% |
0.09% |
|
|
ImpurityD |
<0.3% |
0.14% |
|
|
ImpurityE |
<0.3% |
Not detected |
|
|
Heavy metals |
<20ppm |
<20ppm |
|
|
Loss on drying |
<0.5% |
0.2% |
|
|
Sulphated ash |
<0.1% |
0.05% |
|
Assay by HCLO4(Titration) |
99.0-101.0% |
99.5% |
|
|
Conclusion |
The results conforms with EP7.0 standards. |
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