Hefei TNJ chemical industry co.,ltd
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ISO
97240-79-4 Topiramate
Topiramate in stock
High quality Topiramate
Topiramate powder
|
TESTING SPECIFICATION |
USP 32 |
|
ITEM TESTED |
STANDARD |
|
Appearance |
White to off-white powder. Freely soluble in dichloromethane |
|
Identification |
Infrared Absorption |
|
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation , as obtained in the Assay |
|
|
Specific rotation |
Between -28.6° and -35.0°,measured at 20° |
|
Water |
Not more than 0.5% |
|
Residue on Ignition |
Not more than 0.1% |
|
Heavy metals |
Not more than 10ppm |
|
Related compounds by HPLC (Test 1) |
Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% |
|
Limit of sulfamate and sulfate |
Sulfamate ion not more than 0.10%; Sulfate ion not more than 0.10%. |
|
Assay |
Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis. |
1, Introduction of Topiramate
Topiramate, with the systematic name of beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate, is one kind of white powder. This chemical belongs to the Product Categories which include Active Pharmaceutical Ingredients; APIs; Health & Beauty; Carbohydrates & Derivatives; Pharmaceuticals; Glutamate receptor. It is used as an anticonvulsant and an antidepressant. It is also used to treat Post Traumatic Stress Disorder.
2. Properties of Topiramate
Topiramate has the properties:
(1)Molecular Formula: C12H21NO8S;
(2)Molecular Weight: 339.362040 g/mol;
(3)Index of Refraction: 1.497;
(4)Molar Refractivity: 74.32 cm3;
(5)Molar Volume: 253.8 cm3;
(6)Surface Tension: 53.3 dyne/cm;
(7)Density: 1.336 g/cm3;
(8)Flash Point: 219.1 °C;
(9)Enthalpy of Vaporization: 69.55 kJ/mol;
(10)Boiling Point: 438.7 °C at 760 mmHg;
(11)Vapour Pressure: 6.76E-08 mmHg at 25 °C;
(12)Melting Point: 125°C ;
(13)DMSO Solubility : ~44 mg/mL;
